SMARTBIOCONTROL - Portefeuille de projets - Plateforme transfrontalière de recherche et de formation pour la promotion du biocontrôle des agents phytopathogènes


Flissi, A., Campart, C., Ricart, E., Chevalier, M., Dufresne, Y., Michalik, J., Jacques, P., Flahaut, C., Lisacek, F., Leclère, V. and Pupin, M. (2020) Norine : update of the nonribosomal peptide resource with a new pipeline to automatize massive sourcing and enhance annotations quality. Nucl. Acids Res. doi 10.1093/nar/gkz1000


Chevalier, M., Ricart, E., Hanozin, E., Lisacek, F., Pupin, M., Jacques, P., Smargiasso, N., De Pauw, E., Leclère, V. and Flahaut, C. (2019) Kendrick mass defect approach combined to NORINE database for molecular formula assignment of nonribosomal peptides. Am. Soc. Mass Spec. doi 10.1007/s13361-019-02314-3

Olumide Owolabi OmoboyeNiels Geudens Matthieu DubanMickael ChevalierChristophe FlahautJosé Martins Valérie LeclèreFeyisara Eyiwumi Oni and Monica Hofte (2019). Pseudomonas sp. COW3 Produces New Bananamide-Type Cyclic Lipopeptides with Antimicrobial Activity against Pythium myriotylum and Pyricularia oryzaeMolecules, 24 (22).

Hannah BrückFrank DelvignePascal DhulsterPhilippe JacquesFrançois Coutte (2019). Molecular strategies for adapting Bacillus subtilis 168 biosurfactant production to biofilm cultivation mode. Bioresource Technology, 293.

Olumide Owolabi Omoboye, Feyisara Eyiwumi Oni, Humaira Batool, Henok Zimene  Yimer, René De Mot and Monica Höfte (2019). Pseudomonas cyclic lipopeptides suppress the rice blast fungus Magnaporthe oryzae by induced resistance and direct antagonism. Frontiers in Plant Science, 10: 901. doi:

Marine Rondeau, Qassim Esmaeel, Jérôme Crouzet, Pauline Blinb, Isabelle Gosselin, Catherine Sarazin, Miguel Pernes, Johnny Beaugrandd, Florence Wisniewski-Dyée, Ludovic Viale, Denis Faureb, Christophe Clément, Essaïd Ait Barka, Cédric Jacquard and Lisa Sanchez (2019). Biofilm constructing variants of Paraburkholderia phytofirmans PsJN outcompete the wild-type form in free-living conditions but not in planta. Appl Environ Microbiol. DOI:

Berth, A., Lecouturier, D., Loubiere, K., Dhulster, P., Delaplace, G(2018). Modelling and optimisation of gas-liquid mass transfer in a microporous hollow fiber membrane aerated bioreactor used to produce surfactin. Biochemical Engineering Journal, 145: 109-119.

Feyisara Eyiwumi Oni, Niels Geudens, Olumide Owolabi Omoboye, Lien Bertier, Hoang Gia Khuong Hua, Amayana Adiobo, Davy Sinnaeve, Jose C. Martins and Monica Hofte (2019). Fluorescent Pseudomonas and cyclic lipopeptide diversity in the rhizosphere of cocoyam (Xanthosoma sagittifolium). Environmental Microbiology, 21(3): 1019 – 1034. doi:10.1111/1462-2920.14520.

Ricart Emma, Leclère Valerie, Flissi Areski, Mueller Marcus, Pupin Maude and Lisacek Frédérique (2019). rBAN: retro-biosynthetic analysis of nonribosomal peptides. JCheminform

doi: 10.1186/s13321-019-0335-x

Sarah Le Guenic, Ludovic Chaveriat, Vincent Lequart, Nicolas Joly, Patrick Martin. Renewable surfactants for biochemical applications and nanotechnology. Journal of Surfactants and Detergents (2018)

DOI 10.1002/jsde.12216

Abdellaziz, L., Chollet, M., Abderrahmani, A., Béchet, M., Yaici, L., Chataigné, G., Arguelles Arias, A., Leclère, V. and Jacques, P. (2018). Lipopeptide biodiversity in antifungal Bacillus strains isolated from Algeria.  Archives of Microbiology,

Pupin, M., Flissi, A., Jacques, P. et Leclère, V. (2018) Bioinformatics tools for the discovery of new lipopeptides with biocontrol applications. European Journal of Plant Pathology

Qassim Esmaeel, Lidiane Miotto, Marine Rondeau, Valérie Leclère, Christophe Clément, Cédric Jacquard, Lisa Sanchez and Essaid Ait Barka. Paraburkholderia phytofirmans PsJN-Plants Interaction: From Perception to the Induced Mechanisms. Front. Microbiol., 30 August 2018

Esmaeel, Q., Sanchez, L., Robineau, M., Dorey, S., Clément, C., Jacquard, C., & Barka, E. A. (2018). Draft Genome Sequence of Plant Growth-Promoting Burkholderia sp. Strain BE12, Isolated from the Rhizosphere of Maize. Genome announcements6(17), e00299-18.


Gabriela Mihalache, Tiberius Balaes, Irina Gostin, Marius Stefan, François Coutte and François Krier. Lipopeptides produced by Bacillus subtilis as new biocontrol products against fusariosis in ornamental plants. 2017. Environ Sci Pollut Res

DOI 10.1007/s11356-017-9162-7

Debarun Dhali, François Coutte, Anthony Argüelles Arias, Sandrine Auger, Vladimir Bidnenko, Gabrielle Chataigné, Michael Lalk, Joachim Niehren, Joana de Sousa, Cristian Versari and Philippe Jacques. Genetic engineering of the branched fatty acid metabolic pathway of Bacillus subtilis for the overproduction of surfactin C14 isoform. 2017. Biotechnology Journal

DOI 10.1002/biot.201600574

François Coutte, Didier Lecouturier, Krasimir Dimitrov, Jean-Sébastien Guez, Franck Delvigne, Pascal Dhulster and Philippe Jacques. Microbial lipopeptide production and purification bioprocesses, current progress and future challenges. 2017 Biotechnology Journal

DOI 10.1002/biot.201600566

Yaseen, Y., Gancel, F., Béchet, M., Drider, D., Jacques, P. Study of the correlation between fengycin promoter expression and its production by Bacillus subtilis under different culture conditions and the impact on surfactin production. 2017Archives of Microbiology.

doi: 10.1007/s00203-017-1406-x

Coutte, F., Lecouturier, D., Dimitrov, K., Guez, J.-S., Delvigne, F., Dhulster, P., Jacques, P. Microbial lipopeptide production and purification bioprocesses, current progress and future challenges. 2017.

DOI: 10.1002/biot.201600566

Yaseen, Y., Gancel, F., Drider, D., Béchet, M., Jacques, P. Influence of promoters on the production of fengycin in Bacillus spp. (2016) . Research in Microbiology.

DOI: 10.1016/j.resmic.2016.01.008

Esmaeel, Q., Pupin, M., Jacques, P., Leclère, V. Nonribosomal peptides and polyketides of Burkholderia: new compounds potentially implicated in biocontrol and pharmaceuticals (2018) Environmental Science and Pollution Research.

DOI: 10.1007/s11356-017-9166-3

Abdellaziz, L., Chollet, M., Abderrahmani, A., Béchet, M., Yaici, L., Chataigné, G., Arias, A.A., Leclère, V., Jacques, P. Lipopeptide biodiversity in antifungal Bacillus strains isolated from Algeria (2018) Archives of Microbiology.

DOI: 10.1007/s00203-018-1537-8

Al-Ali, A., Deravel, J., Krier, F., Béchet, M., Ongena, M., Jacques, P. Biofilm formation is determinant in tomato rhizosphere colonization by Bacillus velezensis FZB42 (2018) Environmental Science and Pollution Research.

DOI: 10.1007/s11356-017-0469-1

Yaseen, Y., Diop, A., Gancel, F., Béchet, M., Jacques, P., Drider, D. Polynucleotide phosphorylase is involved in the control of lipopeptide fengycin production in Bacillus subtilis (2018) Archives of Microbiology.

DOI: 10.1007/s00203-018-1483-5

Jacques, P., Béchet, M., Bigan, M., Caly, D., Chataigné, G., Coutte, F., Flahaut, C., Heuson, E., Leclère, V., Lecouturier, D., Phalip, V., Ravallec, R., Dhulster, P., Froidevaux, R. High-throughput strategies for the discovery and engineering of enzymes for biocatalysis (2017) Bioprocess and Biosystems Engineering.

DOI: 10.1007/s00449-016-1690-x

Pupin, M., Esmaeel, Q., Flissi, A., Dufresne, Y., Jacques, P., Leclère, V. Norine: A powerful resource for novel nonribosomal peptide discovery (2016) Synthetic and Systems Biotechnology.

DOI: 10.1016/j.synbio.2015.11.001

Esmaeel, Q., Pupin, M., Kieu, N.P., Chataigné, G., Béchet, M., Deravel, J., Krier, F., Höfte, M., Jacques, P., Leclère, V. Burkholderia genome mining for nonribosomal peptide synthetases reveals a great potential for novel siderophores and lipopeptides synthesis (2016) MicrobiologyOpen.

DOI: 10.1002/mbo3.347

Yaseen, Y., Gancel, F., Drider, D., Béchet, M., Jacques, P. Influence of promoters on the production of fengycin in Bacillus spp. (2016) Research in Microbiology.

DOI: 10.1016/j.resmic.2016.01.008

Leclère, V., Weber, T., Jacques, P., Pupin, M. Bioinformatics tools for the discovery of new nonribosomal peptides (2016) Methods in Molecular Biology.

DOI: 10.1007/978-1-4939-3375-4_14

Esmaeel, Q., Jacquard, C., Clément, C., Sanchez, L., Ait Barka, E. Genome sequencing and traits analysis of Burkholderia strains reveal a promising biocontrol effect against grey mould disease in grapevine (Vitis vinifera L.) (2019) World Journal of Microbiology and Biotechnology.

DOI: 10.1007/s11274-019-2613-1

Olorunleke, F.E., Kieu, N.P., De Waele, E., Timmerman, M., Ongena, M., Höfte, M. Coregulation of the cyclic lipopeptides orfamide and sessilin in the biocontrol strain Pseudomonas sp. CMR12a (2017) MicrobiologyOpen.

DOI: 10.1002/mbo3.499

Ma, Z., Ongena, M., Höfte, M. The cyclic lipopeptide orfamide induces systemic resistance in rice to Cochliobolus miyabeanus but not to Magnaporthe oryzae (2017) Plant Cell Reports.

DOI: 10.1007/s00299-017-2187-z

Claerbout, J., Venneman, S., Vandevelde, I., Decombel, A., Bleyaert, P., Volckaert, A., Neukermans, J., Höfte, M. First report of Fusarium oxysporum f. Sp. lactucae race 4 on lettuce in Belgium (2018) Plant Disease.

DOI: 10.1094/PDIS-10-17-1627-PDN

Ma, Z., Hoang Hua, G.K.H., Ongena, M., Höfte, M. Role of phenazines and cyclic lipopeptides produced by pseudomonas sp. CMR12a in induced systemic resistance on rice and bean (2016) Environmental Microbiology Reports

DOI: 10.1111/1758-2229.12454

Mejri, S., Siah, A., Coutte, F., Magnin-Robert, M., Randoux, B., Tisserant, B., Krier, F., Jacques, P., Reignault, P., Halama, P. Biocontrol of the wheat pathogen Zymoseptoria tritici using cyclic lipopeptides from Bacillus subtilis (2018) Environmental Science and Pollution Research.

DOI: 10.1007/s11356-017-9241-9

Bocquet, L., Rivière, C., Dermont, C., Samaillie, J., Hilbert, J.-L., Halama, P., Siah, A., Sahpaz, S. Antifungal activity of hop extracts and compounds against the wheat pathogen Zymoseptoria tritici (2018) Industrial Crops and Product.

DOI: 10.1016/j.indcrop.2018.05.061

Siah, A., Bomble, M., Tisserant, B., Cadalen, T., Holvoet, M., Hilbert, J.-L., Halama, P., Reignault, P. Genetic structure of zymoseptoria tritici in northern France at region, field, plant, and leaf layer scales (2018) Phytopathology

DOI: 10.1094/PHYTO-09-17-0322-R

Ors, M.E., Randoux, B., Selim, S., Siah, A., Couleaud, G., Maumené, C., Sahmer, K., Halama, P., Reignault, P. Cultivar-dependent partial resistance and associated defence mechanisms in wheat against Zymoseptoria tritici (2018) Plant Pathology

DOI: 10.1111/ppa.12760

Raveschot, C., Cudennec, B., Coutte, F., Flahaut, C., Fremont, M., Drider, D., Dhulster, P. Production of bioactive peptides by lactobacillus species: From gene to application (2018) Frontiers in Microbiology.

DOI: 10.3389/fmicb.2018.02354

Ors M., Randoux B., Siah A., Couleaud G., Maumene C., Sahmer K., Reignault Ph., Halama P., Selim S. (2019). A plant nutrient- and microbial protein-based resistance inducer elicits wheat cultivar-dependent resistance against Zymoseptoria triticiPhytopathology, 109:2033-2045.

Roumy V., Ruiz Macedo JC., Bonneau N., Samaillie J., Azaroual N., Encinas LA., Rivière C., Hennebelle T., Sahpaz S., Antherieu S., Pinçon C., Neut C., Siah A., Gutierrez-Choquevilca AL., Ruiz L. (2019). Plant therapy in the Peruvian Amazon (Loreto) in case of infectious diseases and its antimicrobial evaluation. Journal of Ethnopharmacology, 18:112411.

Raulo R., Heuson E., Siah A., Phalip V. (2019). Froidevaux R. Innovative microscale workflow from fungi cultures to cell wall‐degrading enzyme screening. Microbial Biotechnology, 12: 1286-1292.

Hassine M., Siah A., Hellin P., Cadalen T., Halama P., Hilbert J.L., Hamada W., Baraket M., Yahyaoui A., Legrève A, Duvivier M. (2019). Sexual reproduction of Zymoseptoria tritici on durum wheat in Tunisia revealed by presence of airborne inoculum, fruiting bodies and high levels of genetic diversity.  Fungal Biology, 123: 763-772.

Le Mire G., Siah A., Brisset M.N, Maumené C., Brostaux Y., Massart S., Gaucher M., Jijakli M.H. (2019). Evaluation of λ-carrageenan, CpG-ODN, glycine betaine, Spirulina platensis and ergosterol as elicitors for the control of Zymoseptoria tritici in wheat. Phytopathology, 109: 409-417.

Mejri S., Siah A., Abuhaie C-M., Halama P., Magnin-Robert M., Randoux B., Reignault Ph., Rigo B., Ghinet A. (2018). Salicylic acid and pyroglutamic acid conjugated derivatives confer protection to bread wheat against Zymoseptoria triticiJournal of the Science of Food and Agriculture, 15: 1780-1786.

Fernandez D., Höfte M., Hückelhoven R., Reignault P., Sache I., Siah A. (2018). Special issue “Deepen knowledge in plant pathology for innovative agroecology”. European Journal of Plant Pathology, 152: 853–854.

Le Mire G., Siah A., Brisset M-N., Gaucher M., Deleu M., Jijakli M.H. (2018). Surfactin protects wheat against Zymoseptoria tritici and activates both salicylic acid- and jasmonic acid-dependent defense responses. Agriculture, 8, 11.

Sahli R., Rivière C., Siah A., Smaoui A., Samaillie J., Hennebelle T., Roumy V., Ksouri R., Halama P., Sahpaz S. (2018). Biocontrol activity of effusol from Juncus maritimus extremophile plant against the wheat pathogen Zymoseptoria triticiEnvironmental Science and Pollution Research, 25: 29775-29783.

Somai-Jemmali L., Randoux B., Siah A., Magnin-Robert M., Halama P., Reignault Ph., Hamada W. (2017). Similar infection process and induced defense patterns during compatible interactions between Zymoseptoria tritici and both bread and durum wheat species. European Journal of Plant Pathology, 147: 787-801.

Somai-Jemmali L., Siah A., Harbaoui K., Ferjaoui S., Halama P., Reignault Ph., Hamada W. (2017). Correlation between fungal penetration, CWDE activities and defense-related genes with resistance of Tunisian durum wheat cultivars to Zymoseptoria triticiPhysiological and Molecular Plant Pathology, 100: 117-125.

Cheval P., Siah A., Bomble M., Popper A.D., Reignault Ph., Halama P. (2017). Evolution of QoI resistance of the wheat pathogen Zymoseptoria tritici in Northern France. Crop Protection, 92: 131-133.